Benzofuran 2-carbox amides useful as inhibitors of leukoriene bi

Details Benzofuran 2-carbox amides useful as inhibitors of leukoriene bi Benzofuran 2-carbox amides useful as inhibitors of leukoriene bi

1989-01-30

1990-06-12

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514337, 514382, 514466, 514469, 546196, 546269, 548251, 549435, 549467, A61K 3134, C07D30785

Patent

active

049333518

ABSTRACT:
Compounds of the Formula I: ##STR1## and pharmaceutically acceptable salts thereof are inhibitors of leukotriene biosynthesis. These compounds inhibit the mammalian 5-lipoxygenase enzyme, thus preventing the metabolism of arachidonic acid to the leukotrienes. These compounds are thus useful in the treatment of asthma, allergic disorders, inflammation, skin diseases and certain cardiovascular disorders.

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