Benzodioxole derivatives and pharmaceutical use thereof

Details Benzodioxole derivatives and pharmaceutical use thereof Benzodioxole derivatives and pharmaceutical use thereof

1982-04-19

1983-11-08

Raymond, Richard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2603303, 2603309, 42424857, 424267, 424274, 424275, 424282, 544146, 544148, 544333, 546146, 546168, 546174, 546197, 546270, 548159, 548200, 548204, 548217, A61K 31335, C07D31768

Patent

active

044142145

ABSTRACT:
The invention relates to novel benzodioxole derivatives of the formula I ##STR1## in which R.sub.1 represents an unsubstituted or substituted, aromatic or heteroaromatic radical, alk represents an alkylene or alkylidene radical having a maximum of 5 carbon atoms, n represents 0 or 1, R.sub.2 and R.sub.3 each represents, independently of the other, hydrogen, lower alkyl, lower alkoxy or halogen, and A represents the radical O--R.sub.4, wherein R.sub.4 represents hydrogen or an unsubstituted or substituted, aliphatic or araliphatic hydrocarbon radical, or A represents the radical ##STR2## in which either R.sub.5 and R.sub.6 each represents, independently of the other, hydrogen or lower alkyl, or R.sub.5 and R.sub.6 are bonded to one another and, together with the adjacent nitrogen atom, represent unsubstituted or lower alkyl-substituted tetra- or hexa-methyleneimino or 4-morpholinyl, to salts of compounds of the formula I in which A represents OR.sub.4 wherein R.sub.4 is hydrogen, with bases, and to acid addition salts of compounds of the formula I in which the radical R.sub.1 has a basic character, and to pharmaceutical compositions that contain them. The novel substances exhibit diuretic and, in addition, uricosuric activity and may be administered, according to the invention, preferably in the form of appropriate pharmaceutical compositions, to mammals for the treatment of oedema and hypertension.

REFERENCES:
patent: 3758506 (1973-10-01), Jacques et al.
patent: 3872105 (1975-03-01), Grisar et al.
patent: 3958004 (1976-05-01), Cragoe, Jr. et al.
patent: 4058559 (1977-11-01), Jones et al.
patent: 4156011 (1979-05-01), Lafon et al.
patent: 4220801 (1980-10-01), Walter et al.
Mastrocola et al., Chemical Abstracts, 91, 193158t, (1979).

Affiliated with

Also associated with

Rating

Benzodioxole derivatives and pharmaceutical use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzodioxole derivatives and pharmaceutical use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzodioxole derivatives and pharmaceutical use thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2007497