Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1983-08-08
1985-05-14
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
2602444, 2603303, 2603309, 544131, 544146, 544148, 549 60, 549535, 549536, 546194, 546197, 546270, 548526, 514239, 514338, 514444, 514465, A61K 31455, C07D40706
Patent
active
045171840
ABSTRACT:
The invention relates to novel benzodioxole derivatives of the formula I ##STR1## in which R.sub.1 represents an unsubstituted or substituted, aromatic or heteroaromatic radical, alk represents an alkylene or alkylidene radical having a maximum of 5 carbon atoms, n represents O or 1, R.sub.2 and R.sub.3 each represents, independently of the other, hydrogen, lower alkyl, lower alkoxy or halogen, and A represents the radical O-R.sub.4, wherein R.sub.4 represents hydrogen or an unsubstituted or substituted, aliphatic or araliphatic hydrocarbon radical, or A represents the radical ##STR2## in which either R.sub.5 and R.sub.6 each represents, independently of the other, hydrogen or lower alkyl, or R.sub.5 and R.sub.6 are bonded to one another and, together with the adjacent nitrogen atom, represent unsubstituted or lower alkyl-substituted tetra- or hexa-methyleneimino or 4-morpholinyl, to salts of compounds of the formula I in which A represents OR.sub.4 wherein R.sub.4 is hydrogen, with bases, and to acid addition salts of compounds of the formula I in which the radical R.sub.1 has a basic character, and to pharmaceutical compositions that contain them. The novel substances exhibit diuretic and, in addition, uricosuric activity and may be administered, according to the invention, preferably in the form of appropriate pharmaceutical compositions, to mammals for the treatment of oedema and hypertension.
REFERENCES:
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patent: 4414214 (1983-11-01), Habicht et al.
Mastrocola et al., Chemical Abstracts, vol. 91, (1979) 193158t.
Habicht Ernst
Zbinden Paul
Ciba-Geigy Corporation
Feit Irving N.
Raymond Richard L.
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