Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1983-10-25
1985-01-29
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548430, A61K 3140, C07D20948
Patent
active
044965796
ABSTRACT:
Compounds are disclosed of general formula ##STR1## where R is H, C.sub.1-6 alkyl optionally substituted by C.sub.3-7 cycloalkyl, C.sub.3-6 alkenyl or alkynyl, C.sub.3-7 cycloalkyl, aralkyl or --CHO
and the physiologically acceptable salts thereof. The compounds have selective .alpha..sub.2 -adrenoreceptor antagonist action and are indicated as potentially useful for the treatment or prevention of migraine, thrombosis, diabetes, obesity, hypertension, constipation, paralytic ileus, senile dementia and analepsis, and for use in appetite suppression and for the treatment of depression; they may be formulated as pharmaceutical compositions in conventional manner. The compounds may be prepared, for example, by amination of a compound of formula ##STR2## where X is a leaving group such as halogen or a hydrocarbylsulphonyloxy group.
REFERENCES:
Berthold, Helvetica Chimica Acta, vol. 55, 1972, pp. 2461-2467.
Albert Funke, Chem. Abst., vol. 56, 1962, 14257i.
Marini-Bettolo, Chem. Abst., vol. 52, 1958, 16356h.
Borthwick Alan D.
Crame Andrew J.
Daus Donald G.
Glaxo Group Limited
Shen Cecilia
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