Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-02-08
2005-02-08
Berch, Mark L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S492000, C540S545000, C514S211080
Reexamination Certificate
active
06852714
ABSTRACT:
The present invention of compounds of formula (I)a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, wherein Alk1is C1-6alkanediyl optionally substituted with hydroxy, C1-4alkyloxy or C1-4alkylcarbonyloxy; -Z1-Z2- is a bivalent radical; R1, R2and R3are each independently selected from hydrogen, C1-6alkyl, hydroxy, halo and the like; or when R1and R2are on adjacent carbon atoms, R1and R2taken together may form a bivalent radical; R4is hydrogen or C1-6alkyl; A is a bivalent radical of formula —NR6-Alk2-(b-1), or -Npiperidinyl-(CH2)m(b-2) wherein m is 0 or 1; R5is a radical of formulawherein n is 1 or 2; p1is 0, and p2is 1 or 2; or p1is 1 or 2, and p2is 0; X is oxygen, sulfur or ═NR9; Y is oxygen or sulfur; R7is hydrogen, C1-6alkyl, C3-6cycloalkyl, phenyl or phenylmethyl; R8is C1-6alkyl, C3-6cycloalkyl phenyl or phenylmethyl; R9is cyano, C1-6alkyl, C3-6cyclo-alkyl, C1-6alkyloxycarbonyl or aminocarbonyl; R10is hydrogen or C1-6alkyl; and Q is a bivalent radical. Processes for preparing said products, formulations comprising said products and their use as a medicine are disclosed, in particular for treating conditions which are related to impaired fundic relaxation.
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De Bruyn Marcel Frans Leopold
Schroven Marc Francis Josephine
Verschueren Wim Gaston
Wigerinck Piet Tom Bert Paul
Berch Mark L.
Habte Kahsay
Janssen Pharmaceutica N.V.
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