Benzodioxa alkylene ethers as melatonergic agents

Details Benzodioxa alkylene ethers as melatonergic agents Benzodioxa alkylene ethers as melatonergic agents

1998-10-09

1999-11-09

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514452, 514466, 549350, 549362, 549441, C07D31760, C07D31908, A61K 3136, A61K 3135

Patent

active

059815710

ABSTRACT:
Novel derivatives of benzodioxa alkylene ethers are provided which are useful as melatonergic agents.

REFERENCES:
patent: 5596019 (1997-01-01), Mattson et al.
Arendt, J., et al., "Alleviation of Jet Lag by Melatonin: Preliminary Results of Controlled Double Blind Trial", Br. Med. J., 292, pp. 1170-1172 (May 1986).
Cassone, V.M., et al., "Dose-Dependent Entrainment of Rat Circadian Rhythms by Daily Injection of Melatonin", J. Biol. Rhythms, 1, (3), pp. 219-229 (1986).
Copinga, S., et al., "2-Amino-8-methoxytetralins: A Series of Nonindolic Melatonin-like Agents", J. Med. Chem., 36, pp. 2891-2898 (1993).
Reppert, S.M., et al., "Cloning and Characterization of a Mammalian Melatonin Receptor That Mediates Reproductive and Circadian Responses", Neuron, 13, pp. 1177-1185 (Nov. 1994).
Reppert, S.M., et al., "Molecular Characterization of a Second Melatonin Receptor Expressed in Human Retina and Brain: The Mel.sub.1b Melatonin Receptor", Proc. Natl. Acad. Sci. USA, 92, pp. 8734-8738 (Sep. 1995).

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