Benzodiazepine radioimmunoassay using I125-label

Details Benzodiazepine radioimmunoassay using I125-label Benzodiazepine radioimmunoassay using I125-label

1977-04-04

1978-04-11

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

23230B, 260112R, 2602393D, 424 8, 424 12, A61K 4300, G01N 3316, C07G 700

Patent

active

040839486

ABSTRACT:
An improved radioimmunoassay for benzodiazepines such as diazepam, chlordiazepoxide, oxazepam, demoxepam and metabolites thereof is disclosed. Such immunoassay employs novel .sup.125 I-labelled 4'-hydroxy derivatives of these compounds as tracer.

REFERENCES:
patent: 3335295 (1967-08-01), Sternbach et al.
patent: 3336296 (1967-08-01), Bell et al.
patent: 3338886 (1967-08-01), Berger et al.
patent: 3546212 (1970-12-01), Felix et al.
patent: 4022878 (1977-05-01), Gross
Rejent et al., Clinical Chemistry, vol. 22, No. 6, June, 1976, pp. 889-891.
Dixon et al., Journal of Pharmaceutical Sciences, vol. 64, No. 6, June, 1975, pp. 937-939.
Peskar et al., The Journal of Pharmacology and Experimental Therapeutics, vol. 186, No. 1, July, 1973, pp. 167-172.

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