Benzodiazepine protein conjugates

Details Benzodiazepine protein conjugates Benzodiazepine protein conjugates

1996-01-24

1997-09-02

Feisee, Lila

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

514686, 530402, 540507, 540512, 540514, A61K 4500, C07D24328

Patent

active

056629117

ABSTRACT:
Benzodiazepine protein conjugates of the formula I ##STR1## wherein R1 is hydrogen, a methyl group or R, R2 is hydrogen, a hydroxyl or an OR group, with R1 or R2 containing an R group,
R3 is a halogen, NO2 or NH2,
X is hydrogen or a halogen,
wherein R is a group of the formula II, wherein Z is a macromolecular immunogen reactive carrier substance and n is 2 or 3.
The benzodiazepine protein conjugates are used as immunogens to obtain antibodies to benzodiazepines.
The invention also relates to an immunoassay for the detection of benzodiazepines where the so generated antibodies are used.

REFERENCES:
patent: 4046636 (1977-09-01), Ullmann et al.
patent: 5434052 (1995-07-01), Khanna
Randall & Banziger, J. Med. Chem. 1965, 8 :815-812.
Current Protocols in Mol Bio, Ausubel et al., Eds (Green Pub. Ass. & Wiley-Interscience, 1992, p. 11.1.2).
Harlow & Lane, Antibodies, Cold Spring Harbor Lab, 1988, p. 72.

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