Benzodiazepine derivatives, compositions containing them and the

Details Benzodiazepine derivatives, compositions containing them and the Benzodiazepine derivatives, compositions containing them and the

1993-02-12

1995-09-19

Rizzo, Nicholas

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540509, C07D24324, A61K 3155

Patent

active

054515823

ABSTRACT:
Compounds of formula (I), and salts and prodrugs thereof ##STR1## wherein: R.sup.1 is H, certain optionally substituted C.sub.1.6 alkyl, or C.sub.3-7 cycloalkyl;
R.sup.2 is (CH.sub.2).sub.q -tetrazolyl optionally substituted in the tetrazole ring by C.sub.1-4 alkyl, (CH.sub.2).sub.q -imidazolyl (where q is 0, 1, 2 or 3), CONHSO.sub.2 R.sup.9, SO.sub.2 NHCOR.sup.9 (where R.sup.9 is C.sub.1-6 alkyl, optionally substituted aryl or trifluoromethyl). SO.sub.2 NHR.sup.10 (where R.sup.10 is a nitrogen containing heterocycle), cyclopropyl or (CH.sub.2), CO.sub.2 H, where n is 1 or 2;
R.sup.3 is C.sub.1-6 alkyl, halo or NR.sup.6 R.sup.7 ;
R.sup.4 is C.sub.1-7 straight or branched chain alkyl; and
x is 0, 1, 2 or 3;
are CCK and/or gastrin receptor antagonists. They and compositions thereof are useful in therapy.

REFERENCES:
patent: 4820834 (1989-04-01), Evans et al.
patent: 5010076 (1991-04-01), Waldeck et al.
patent: 5175159 (1992-12-01), Bock et al.
patent: 5302591 (1994-04-01), Fletcher et al.
patent: 5360802 (1994-11-01), Chambers et al.
Chemical Abstracts vol. 119(13): 139279s (1993).
Chemical Abstracts vol. 118(11): 101998s (1993).
Life, Sci. 30, 479 (1982), by J. E. Morley.
Br. J. Pharmacol, 105, pp. 8-10 (1992), by Singh, et al.
J. Med. Chem., 32, pp. 13-16 (1989), by M. Bock, et al.

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