Benzodiazepine derivatives, compositions containing them and the

Details Benzodiazepine derivatives, compositions containing them and the Benzodiazepine derivatives, compositions containing them and the

1992-11-13

1994-11-01

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540509, A61K 3155, C07D24324, C07D24310

Patent

active

053608020

ABSTRACT:
This invention relates to benzodiazepine compounds which are useful as antagonists of cholecystokinin and gastrin.

REFERENCES:
patent: 4820834 (1989-04-01), Evans et al.
patent: 5010076 (1991-04-01), Waldeck et al.
V. Mutt, Gastrointestinal Hormones, G. B. J. Green, Ed., Raven Press, N.Y. p. 169 and G. Nission, ibid p. 127.
Mutt and Jorpes, Biochem. J. 125 678 (1981).
A. J. Stunkard and E. Stellar, Eds. Raven Press, New York, 1984, p. 67.
A. J. Prange, et al., "Peptides in the Central Nervous System", Ann Repts. Med. Chem. 17, 31, 33 91982).
J. A. Williams, Biomed. Res. 3 107 (1982).
J. E. Morley, Life, Sci. 30, 479 (1982).
T. H. Moran, et al "Two Brain cholecystokinin receptors: implications for behavoural actions", Brain Res., 175-79 (1986).
P. L. Faris, et al Science, 226 1215 (1984).
M. F. O'Neill, et al., Brain Research, 534 287 (1990).
Rasmusson, et al., (1991) Eur. J. Pharmacol., 209, 135-38.
Woodruff, et al., 1991, Neuropeptides 19, 45-46.
Cervo, et al., 1988 Eur. J. Pharmacol., 158, 53-59.
Singh, et al 1992, Br. J. Pharmacol., 105 8-10.
K. Okyama, Hokkaido J. Med. Sci., 206-216 (1985).
Xu, et al., Peptides, 8, (1987) 769-772.
A. Bill, et al., Acta Physiol. Scand., 138 479-485 (1990).
M. Bock, et al., J. Med. Chem., 32 13-16 (1989).
Beauchamp, et al., Ann. Surg., 202, 203 (1985) (Cumulative).
Soc. Neurosci. Abstr., vol. 14, p. 291 (1988) by Bradwejn, et al.
Soc. Neurosci. Abstr., vol. 14, p. 291 (1988), by de Montigny.
Nature, vol. 312, p. 22 (1984), by Bradwejn, et al.
Arch. Gen Psych., vol. 46, pp. 511-517 (1989), by de Montigny.
Eur. J. of Pharma., vol. 147, pp. 469-472 (1988), by Dourish, et al.
Eur. J. of Pharma., vol. 151, pp. 135-138 (1988), by Bouthillier, et al.
Neuropharmacology, vol. 28, No. 3, pp. 243-247 (1989), by O'Neill, et al.
Proc. Natl. Acad. Sci., vol. 83, pp. 4923-4926 (1986), by Chang, et al.
J. of Med. Chem., vol. 32, No. 1, pp. 13-16 (Jan. 1989), by Bock et al.

Affiliated with

Also associated with

Rating

Benzodiazepine derivatives, compositions containing them and the does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzodiazepine derivatives, compositions containing them and the, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzodiazepine derivatives, compositions containing them and the will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1802736