Benzodiazepine derivatives and their use as antagonists of chole

Details Benzodiazepine derivatives and their use as antagonists of chole Benzodiazepine derivatives and their use as antagonists of chole

1995-09-05

1997-12-09

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514212, 514221, 540467, 540480, 540509, A61K 3155, C07D40104, C07D40304, C07D41304

Patent

active

056961103

ABSTRACT:
##STR1## Compounds of formula (I), and salts and prodrugs thereof, wherein X is O,S,NR.sup.4 or CH.sub.2 ; R.sup.1 represents H, certain optionally substituted C.sub.1-6 alkyl, or C.sub.3-7 cycloalkyl; R.sup.2 represents phenyl having certain optional substituents; R.sup.3 represents C.sub.1-6 alkyl, halo or NR.sup.6 R.sup.7 ; m is 2,3 or 4; n is 1,2,3,4,5,6 7 or 8 when X is CH.sub.2 or 2,3,4,5,6,7 or 8 when X is O, S or NR.sup.4 ; and x is 0,1,2, or 3; are CCK and/or gastrin antagonists. They and compositions thereof are therefore useful in therapy.

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