Benzodiazepine derivatives and their preparation and use

Details Benzodiazepine derivatives and their preparation and use Benzodiazepine derivatives and their preparation and use

1987-03-13

1988-09-20

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

548498, 548504, 548506, A61K 3155, C07D48714, C07D548131, C07D521000

Patent

active

047725990

ABSTRACT:
New benzodiazepine derivatives of the general formula ##STR1## wherein X.sup.1 and X.sup.2 independently are ##STR2## wherein R.sup.1 is C.sub.1-3 -alkyl, C.sub.3-5 -cycloalkyl, C.sub.1-3 -alkoxymethyl, C.sub.1-3 -hydroxyalkyl, or aryl,

REFERENCES:
patent: 4316839 (1982-02-01), Gerecke et al.
patent: 4435403 (1984-03-01), Braestrup et al.
patent: 4507313 (1985-03-01), Braestrup et al.
Squires, Braestrup, "Benzodiazepine Receptors in Rat Brain", Nature, 266, (1977), pp. 732-734.
Litchfield et al., "A Simplified Method of Evaluating Dose-Effect Experiments", Journal of Pharmacology and Experimental Therapeutics, (1949), pp. 99-113.
Hartman et al., "A Novel 1,3-thiazole Synthesis via alpha-metallated isocyanides and thiono esters", Synthesis, (1976), pp. 681-682.
Chang et al., "Benzodiazepine Receptors: Labeling in Intact Animals with [.sup.3 H] Flunitrazepam", Europe. J. Pharmacol., 48, (1978), pp. 213-218.

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