Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1982-12-17
1984-10-02
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
2602393D, 424267, 424274, A61K 3155, C07D24324
Patent
active
044747772
ABSTRACT:
There are presented novel pharmaceutically active substances which inhibit the intestinal resorption of cholesterol and which accordingly can be used in the control or prevention of atherosclerosis. These active substances are benzodiazepines of the formula ##STR1## wherein R.sup.1 is (C.sub.1 -C.sub.4)-alkyl, R.sup.2 is hydrogen or methyl, R.sup.3 and R.sup.4 each are halogen and R.sup.5 is (C.sub.3 -C.sub.9)-alkylamino substituted by at least two hydroxy groups, (C.sub.3 -C.sub.6)-cycloalkylamino substituted by at least one hydroxy group, glucosamino, galactosamino, mannosamino, monohydroxy-1-azetidinyl, mono- or dihydroxy-1-pyrrolidinyl or mono-, di- or trihydroxy-1-piperidinyl,
and the readily hydrolyzable esters and ethers thereof, as well as pharmaceutically acceptable salts of these compounds.
REFERENCES:
patent: 4299767 (1981-11-01), Fischli et al.
Cassal Jean-Marie
Fischli Albert E.
Szente Andre
Bond Robert T.
Hoffman Frank P.
Hoffmann-La Roche Inc.
Leon Bernard S.
Saxe Jon S.
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