Benzodiazepine derivatives and process of making them

Details Benzodiazepine derivatives and process of making them Benzodiazepine derivatives and process of making them

1978-03-16

1981-01-13

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D24316, C07D24506, C07D24324

Patent

active

042448697

ABSTRACT:
1,4-Benzodiazepin of the formula ##STR1## wherein R is a low molecular straight or branched alkyl and X is halogen or trifluoromethyl, and pharmaceutically acceptable acid addition salts of these benzodiazepins. The benzodiazepins are made by heating an acyldiamine in the presence of phosphorus oxychloride at the latter's boiling point followed by reacting the resulting mixture of 7-member and 8-member compounds with an alkali metal alkoxide.

REFERENCES:
patent: 4096141 (1978-06-01), Milkonski et al.

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