Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fungus – except allergen – or component thereof or substance...
Patent
1976-11-02
1979-09-25
Rollins, Alton D.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fungus, except allergen, or component thereof or substance...
26032647, 2603265SF, 2603265J, 2603265FM, 2603473, 260556AR, 260557R, 260558R, 260561R, 2603265B, 2603269, 544372, 548253, 548217, 548236, 548180, 548200, 548262, 2602457, 260326R, 260326A, 260326C, 260326N, 26032614R, 26032635, 26032636, 26032637, A61K 3155, C07D48704
Patent
active
041691504
ABSTRACT:
Novel 4H-pyrrolo[1,2-a][1,4]benzodiazepine derivatives of the formula ##STR1## wherein at least one of R.sub.1, R.sub.2 and R.sub.3 represent lower alkyl and the remainder hydrogen, R.sub.4 represents hydrogen or lower alkyl, ring A optionally contains at least one substituent selected from halogen, nitro and trifluoromethyl, and ring B optionally contains at least one substituent selected from halogen, nitro, trifluoromethyl, lower alkyl and lower alkoxy; and novel intermediates thereof expressed by the formula ##STR2## wherein Z represents protected amino. Compounds of formula (I) are prepared by subjecting compounds of formula (II) to protective group-elimination and cyclization. The compounds of formula (I) and acid addition salts thereof have useful anti-anxietic, sedative, anti-convulsant, muscle relaxant and hypnotic, and their toxicity is low.
REFERENCES:
patent: 3642820 (1972-02-01), Hester
patent: 3917627 (1975-11-01), Hester et al.
patent: 3987052 (1976-10-01), Hester
Garcia et al., J. Org. Chem., vol. 33, pp. 1359-1363, (1968).
Fujimori Hitoshi
Hara Takeshi
Hashimoto Yoshinobu
Ishimoto Sachio
Itoh Kazuhiko
Rollins Alton D.
Teijin Limited
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