Benzodiazepine derivatives

Details Benzodiazepine derivatives Benzodiazepine derivatives

1981-01-16

1982-11-30

Bond, Robert T.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424244, 424246, 42424854, 424270, 424274, 424250, C07D24324

Patent

active

043615112

ABSTRACT:
There are presented compounds of the formula ##STR1## wherein R.sup.1 is a lower alkyl group, R.sup.2 is a hydrogen atom or a lower alkyl group, R.sup.3 is a hydrogen or halogen atom, R.sup.4 is a hydrogen atom or a group of the formula R.sup.5 --CO--,R.sup.6 R.sup.7 N--O--, ##STR2## A is a lower alkylene group, X is an oxygen or sulphur atom or a group of the formula >N--.sup.8 , R.sup.5 is a lower alkyl or lower haloalkyl group, R.sup.6 is a hydrogen atom or a lower alkyl group, R.sup.7 is a lower alkyl group and R.sup.8 is a hydrogen atom or a lower alkyl or lower hydroxyalkyl group, and their pharmaceutically acceptable acid addition salts.
The compounds have aldosterone-antagonistic properties and are accordingly suitable for the control or prevention of heart failure, hepatic ascites, primary aldosteronism and idiopathic hypertension.

REFERENCES:
patent: 3371085 (1968-02-01), Reeder et al.
patent: 3464978 (1969-09-01), Earley et al.
patent: 4251444 (1981-02-01), Fischli et al.

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