Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-02-16
1996-07-30
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540509, A61K 3155, C07D24324, C07D24326
Patent
active
055411827
ABSTRACT:
This invention relates to novel benzodiazepine derivatives represented by the following general formula (I) or pharmaceutically acceptable salts thereof, ##STR1## (wherein R.sup.1 is an aryl group, or an aromatic heterocyclic radical of 5-membered monocyclic, 6-membered monocyclic or 5- and 6-membered bicyclic structure, which may optionally be substituted; and R.sup.2 is an aryl group which may optionally be substituted), to medicinal compositions comprising the same, and to a process for producing the same. The compounds of formula (I) shown above exhibit antagonism for the CCK-B receptor and the action of depressing the gastric acid secretion caused by the stimulus of pentagastrin, and are therefore useful as a drug for the relief of diseases related to the CCK-B receptor and the gastrin receptor.
REFERENCES:
patent: 4820834 (1989-04-01), Evans
Noodruff, Neuropeptides 19, Snppl 45-56 (1991).
Honda Kazuo
Kondoh Yutaka
Nishida Akito
Okamoto Yoshinori
Saito Masayuki
Berch Mark L.
Yamanouchi Pharmaceutical Co. Ltd.
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