Benzocycloheptene derivative and process for preparation thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514422, 5142315, 546206, 548527, 544146, A61K 3138, A61K 31445

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active

052525899

ABSTRACT:
There is disclosed a benzocycloheptene compound of the formula: ##STR1## wherein R.sup.1 is hydrogen atom, a halogen atom or a lower alkoxy group, R.sup.2 and R.sup.3 are independently selected from hydrogen atom, a lower alkyl group and a lower alkenyl group, or R.sup.2 and R.sup.3 combine together with adjacent nitrogen atom to form a heteromonocyclic group, or a pharmaceutically acceptable salt thereof, which has an excellent inhibitory activity against contraction of urinary bladder.

REFERENCES:
patent: 4091115 (1978-05-01), Nedelec et al.
patent: 4777176 (1988-10-01), Worthington et al.
Chemical Abstracts, vol. 62, 11751b (1965).
Thies et al., J. Org. Chem., vol. 45, pp. 185-187 (1980).
Wong et al., J. Med. Chem. vol. 27, pp. 20-27 (1984).
Jones et al., J. Chem. Soc., (C), pp. 2176-2181 (1969).

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