Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1997-04-07
1998-02-17
McKane, Joseph
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
544139, 544360, 544370, 546210, 5482632, 5482638, 5483147, 5483247, 5483245, 564428, 564460, 564462, C07D40304, C07D23360
Patent
active
057192804
ABSTRACT:
The present invention relates to novel benzocycloalkylazolethione compounds which are dopamine .beta.-hydroxylase inhibitors in which the benzocycloalkyl portion of the compound is selected from indanyl, 1,2,3,4-tetrahydronaphthalenyl and 6,7,8,9-tetrahydro-5H-benzocycloheptenyl (in which the benzo is optionally substituted with one to three substituents) and the azolethione portion of the compound is selected from 2-thioxo-2,3-dihydro-1H-imidazol-3-yl, with one to three substituents); and the prodrugs, pharmaceutically acceptable salts, individual isomers and mixtures of isomers and the methods of using and preparing such benzocycloalkylazolethione compounds.
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Gooding Owen Will
Martinez Gregory Ricardo
Repke David Bruce
Teitelbaum Philip Jay
Walker Keith Adrian Murray
McKane Joseph
Syntex (U.S.A.) Inc.
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