Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-09-25
1994-03-22
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514217, 540522, 540523, A61K 3155, C07D22316
Patent
active
052964825
ABSTRACT:
The compounds are 3-[ (benzocycloalkyl)alkyl amino alkyl] -1,3,4,5-te trahydro 2H- 3-benzazepin-2 ones useful in cardiovascular field.
A compound disclosed is (R,S)-7,8-dimethoxy-3-{3-{N-[(4,5-dimethoxybenzocyclobut-1-yl) methyl]-N-methyl amino}propyl}-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one.
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Anders Karlent et al., J. Med. Chem., 1989, 32, 765-774: "Topography and conformational preferences of 6,7,8,9-tetrahydro-1-hydroxy-N,N-dipropy-5H-benzocyclohepten-6-ylamine. A rationale for the dopaminergic inactivity".
J. G. Cannon et al., J. Med. Chem., 1984, 27, 922-923: "Catechol Derivatives of 6-Aminobenzocycloheptene: Assessment of Dopaminergic Effects".
J. G. Cannon et al., J. Med. Chem. 1972, 15(4), 348-350: "Centrally Acting Emetics. 6. Derivatives of beta-Naphthylamine and 2-Indanamine".
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Bidouard Jean-Pierre
Janiak Philip
Peglion Jean-Louis
Vian Joel
Vilaine Jean-Paul
Adir et Compagnie
Berch Mark L.
Hueschen Gordon W.
Sripada P. K.
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