Benzobicycloalkane derivatives as anticonvulsant neuroprotective

Details Benzobicycloalkane derivatives as anticonvulsant neuroprotective Benzobicycloalkane derivatives as anticonvulsant neuroprotective

1990-01-02

1990-09-18

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

A61K 3166

Patent

active

049579096

ABSTRACT:
The use of the compounds: ##STR1## where R is hydrogen, alkyl, alkoxy, hydroxy, alkanoyloxy, phenylalkoxy, halo or trifluoromethyl; R.sup.1 is alkyl, alkenyl or phenylalkyl; R.sup.2 is hydrogen, alkyl, phenylalkyl, alkenyl, alkynyl, thienylalkyl or furylalkyl; n is one of the integers 2, 3, 4, 5 or 6; or a pharmaceutically acceptable salt thereof, as NMDA antagonists in the treatment of convulsions and neurodegenerative disease states. The compounds in which R.sup.2 are heterocyclylalkylamines are novel and useful NMDA antagonists.

REFERENCES:
patent: 4001331 (1977-01-01), Freed et al.
J. Med. Chem. 16, 595 (1973).
J. Med. Chem., 19, 476 (1976).
J. Med. Chem., 19, 560 (1976).

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