Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1986-05-20
1988-01-19
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544361, 546 95, 546137, A61K 31495, C07D40304, C07D40104
Patent
active
047204958
ABSTRACT:
Benzo[ij]quinolizine-2-carboxylic acid derivatives of the general formula [I] and the salts, and their hydrates are provided: ##STR1## wherein A is a methylene group and B is a carbonyl group when A and B are linked by a single bond, or A and B unite together to form a vinylene group when A and B are linked by a double bond, R.sup.1 is a hydrogen atom, a C.sub.1-3 alkyl group or a 2-hydroxyethyl group, R.sup.2 and R.sup.3 are hydrogen atoms, methyl groups or ethyl groups and may be identical to or different from each other, R.sup.3 may be attached to the same carbon atom as R.sup.2, R.sup.4 is a methyl or ethyl group, and X is a halogen atom. The benzo[ij]quinolizine-2-carboxylic acid derivatives and the salts, and their hydrates have good adsorbability from the digestive tract into the circulating blood and exhibit excellent and long-lasting antibacterial activity.
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Kikuchi Toshiaki
Saeki Masaki
Takagi Atsushi
Yajima Masao
Daus Donald G.
Shen Cecilia
Tokyo Tanabe Co. Limited
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