Benzo-fused cycloalkane and oxa- and thia-, cycloalkane trans-1,

Details Benzo-fused cycloalkane and oxa- and thia-, cycloalkane trans-1, Benzo-fused cycloalkane and oxa- and thia-, cycloalkane trans-1,

1989-06-07

1990-05-29

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142335, 514254, 514324, 514432, 514456, 548950, 548525, 549 23, 549404, 544146, 544151, 544376, C07D40704, C07D40904, A61K 3140

Patent

active

049296272

ABSTRACT:
Benzo-fused cycloalkane and oxa- and thia-cycloalkane trans-1,2-diamine compounds of the formula: ##STR1## wherein A, B, C, D, n, X, Y, R, R.sup.1, R.sup.2 and R.sup.3 are as defined in the specification, e.g., trans-3,4-dichloro-N-methyl-N-[2-(pyrrolidin-1-yl)-5-methoxy-1,2,3,4-tetra hydronaphth-1-yl]benezeneacetamide, and the pharmaceutically acceptable salts or N-oxides thereof, are useful as analgesics and/or diuretics.

REFERENCES:
patent: 4098904 (1978-07-01), Szmuszkovicz
patent: 4145435 (1979-03-01), Szmuszkovicz
patent: 4212878 (1980-07-01), Lednicer et al.
patent: 4359476 (1982-11-01), Kaplan
patent: 4360531 (1982-11-01), McMillan
patent: 4438130 (1984-03-01), Kaplan
patent: 4460600 (1984-07-01), Kaplan et al.
patent: 4632935 (1986-12-01), Kaplan
J. Pharmacol. Exp. Ther., 224, 1, (1983).

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