Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1987-12-02
1989-05-09
Fan, Jane T.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514422, 514320, 514464, 514465, 514443, 514324, 546196, 546202, 548525, 544153, 549 51, 549 49, 549468, 549469, 549471, C07D21114, A61K 31445
Patent
active
048290670
ABSTRACT:
Novel benzo-furan(or -thiophene) derivative of the formula: ##STR1## wherein R.sup.1 is hydrogen atom, a lower alkyl group, a cycloalkyl group, a phenyl-lower alkyl group or a substituted or unsubstituted phenyl group, R.sup.2 is hydrogen atom, a lower alkyl group, an acyl group or phenyl group, R.sup.3 is hydrogen atom, a halogen atom, nitro group, a lower alkoxy group, amino group or an acylamino group, R.sup.4 is a group of the formula: ##STR2## A is a lower alkylene group optionally substituted with hydroxy group, B is single bond or a lower alkylene group, one of R.sup.5 and R.sup.6 is hydrogen atom or a lower alkyl group and the other is a lower alkyl group or a phenyl-lower alkyl group, or R.sup.5 and R.sup.6 combine together with adjacent nitrogen atom to form a heteromonocyclic group, R.sup.7 is a lower alkyl group, X is oxygen atom or sulfur atom, Y is oxygen atom, imino group, a lower alkylimino group or a phenyl-lower alkylimino group and a salt thereof are disclosed.
Said compound (I) and a salt thereof have a potent inhibitory activity against reflective contraction of urinary bladder.
REFERENCES:
patent: 3452033 (1969-06-01), Mooradian
patent: 4238487 (1980-12-01), Bicking
Lednicer et al., CA104:19499g.
Woyke et al., CA96:507c.
Zawadowski et al., CA100:120800r.
Iijima Ikuo
Ishizuka Tohru
Nosaka Kunio
Ozeki Masakatsu
Saiga Yutaka
Fan Jane T.
Tanabe Seiyaku Co. Ltd.
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