Benzo[d]isoxazol-3-ol DAAO inhibitors

Details Benzo[d]isoxazol-3-ol DAAO inhibitors Benzo[d]isoxazol-3-ol DAAO inhibitors

2007-01-23

2007-01-23

Saeed, Kamal A. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S379000

Reexamination Certificate

active

11024151

ABSTRACT:
Methods for increasing D-Serine concentration and reducing concentration of the toxic products of D-Serine oxidation, for enhancing learning, memory and/or cognition, or for treating schizophrenia, Alzheimer's disease, ataxia, or neuropathic pain, or preventing loss in neuronal function characteristic of neurodegenerative diseases involve administering to a subject in need of treatment a therapeutic amount of a compound of formula I, or a pharmaceutically acceptable salt or solvate thereof:whereinZ1is N or CR3;Z2is N or CR4;Z3is O or S;A is hydrogen, alkyl or M+;M is aluminum, calcium, lithium, magnesium, potassium, sodium, zinc or a mixture thereof;R1, R2, R3and R4are independently selected from hydrogen, alkyl, hydroxy alkoxy, aryl, acyl, halo, cyano, haloalkyl, NHCOOR5and SO2NH2;R5is aryl, arylalkyl, heteroaryl or heteroarylalkyl;at least one of R1, R2, R3and R4is other than hydrogen; andat least one of Z1and Z2is other than N.

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