Benzo(c)-1,5-naphthyridines useful for treating a patient having

Details Benzo(c)-1,5-naphthyridines useful for treating a patient having Benzo(c)-1,5-naphthyridines useful for treating a patient having

1985-03-13

1987-03-24

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514292, 544361, 546 81, 546 94, 546111, 548428, A61K 31435, C07D40104

Patent

active

046525670

ABSTRACT:
There are disclosed novel compounds of the formula ##STR1## where X is H, halogen, loweralkyl, loweralkoxy, --CF.sub.3, or --OH; R is H, loweralkyl, arylloweralkyl, diarylloweralkyl, loweralkanoyl, arylloweralkanoyl or diarylloweralkanoyl; and R.sub.1 is H.sub.2, O or --NR.sub.2 R.sub.3, R.sub.2 and R.sub.3 being independently H or loweralkyl, or taken together with the nitrogen atom to which they are attached constitute ##STR2## R.sub.4 in turn being H, loweralkyl, hydroxyloweralkyl, aryl, arylloweralkyl or diarylloweralkyl or pharmaceutically acceptable acid addition salts thereof, which are useful for enhancing memory.

REFERENCES:
Kolocouris & Rigo; Chimika Chronika, New Series 11, 309 (1982).
Rigo & Kolocouris, J. Heterocyclic Chem 20, 893, 1983.
Rigo, Fossaet, de Quilarg & Kolocouris, J. Heterocyclic Chem. 21, 1381 (1984).
Ferlux, Chem Abst. 85-32835x, eq. France Pat. No. 2273533.
Bauer & Hewitson, J. Org. Chem. 27, 3982 (1962).
Thyagarjan, Mechanism of Molecular Migrations, 1971, pp. 251-289.
Campaigne, Mathews, J. Heterocyclic Chem. 12, 391 (1975).

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