Benzo[b]thiophenyl or tetrahydro-benzo[b]thiophenyl...

Details Benzo[b]thiophenyl or tetrahydro-benzo[b]thiophenyl... Benzo[b]thiophenyl or tetrahydro-benzo[b]thiophenyl...

2005-10-04

2005-10-04

Desai, Rita (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S381000, C514S438000, C514S443000, C548S250000, C549S032000

Reexamination Certificate

active

06951878

ABSTRACT:
The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like.The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

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A convenient of 3(2)-trifluoroacetylaminobenzo[b]thiophenes and thiophenes and some of their iodo derivatives. Heterocycles (1992), 34(1), Prats, Montserrat et al.
Chemical Abstracts, vol. 116, No. 9, Mar. 2, 1992, The Abstract No. 83486a, Bioorg. Med., Chem Lett. 1991 (9), 455-460.
Salituro, Francesco, et al., Bioorganic & Medicinal Chemistry Letters, (1991), vol. 1, Part 9, pp. 455-460.

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