Benzo[b]thiophene- and benzo[b]furancarboxamide derivatives, pha

Details Benzo[b]thiophene- and benzo[b]furancarboxamide derivatives, pha Benzo[b]thiophene- and benzo[b]furancarboxamide derivatives, pha

1987-06-05

1989-02-28

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514324, 514443, 514469, 546196, 546202, 549 57, 549 60, 549467, A61K 3138, A61K 31445, C07D33368, C07D40902

Patent

active

048085995

ABSTRACT:
Compounds of formula: ##STR1## in which R.sub.1 and R.sub.2 are each alkyl, cycloalkyl or phenyl, or NR.sub.1 R.sub.2 =piperidine, Ar is optionally substituted phenyl or thienyl, and X< is one of the following linkages: ##STR2## are useful as anxiolytic, antianginal and immunomodulatory agents. They may be made by reaction of an amine with the corresponding acid chloride.

REFERENCES:
Zavala et al, European Journal of Pharmacology, vol. 106 (1984), pp. 561-566.
Mestre et al, European Journal of Pharmacology, vol. 112 (1985), pp. 257-260.
Mizoule et al, Life Sciences, vol. 36 (1985), pp. 1059-1068.
Hashem et al, CA, vol. 99, 1983, 99:211859u, p. 586.
Hishmat et al, CA, vol. 100, 1984, 100:22531j, p. 482.
Morrison et al, Textbook "Organic Chemistry", 1973, Allyn and Bacon, Inc., Boston, MA, p. 746.

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