Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-01-31
2010-06-22
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S283000, C544S342000, C546S048000
Reexamination Certificate
active
07741325
ABSTRACT:
A compound selected from those of formula (I):wherein:B1, B2represent carbon or nitrogen,X, Y, X1and Y1represent a group selected from hydrogen, halogen, hydroxy, alkoxy, nitro, cyano, trihaloalkyl and NRaRbwherein Raand Rbare as defined in the description,R1represents hydrogen or alkyl,R2represents a group selected from hydrogen, alkyl, —OR″a, —NR′aR′b, —O-Ta-OR″a, —NR″a-Ta-NR′aR′b, NR″a—C(O)-TaH, —O—C(O)-TaH, —O-Ta-NRa′Rb′, —NR″a-Ta-OR″a, —NR″a-Ta-CO2R″aand —NR″a—C(O)-Ta-NR′aR′bwherein R′a, R′b, R″aand Taare as defined in the description,R3, R4represent hydrogen or alkyl,A represents a group of formula —CH(R5)—CH(R6)—, —CH═C(R7)—, —C(R7)═CH—, —C(O)—CH(R8)— or —CH(R8)—C(O)— wherein R5, R6, R7and R8are as defined in the description,its isomers, N-oxides, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
REFERENCES:
patent: 6288073 (2001-09-01), Koch et al.
The Cecil reference (Cecil Textbook of Medicine, 21st Edition (2000), Goldman & Bennett (Editors), W.B. Saunders Company (Publisher), Chapter 198, pp. 1060-1074).
Internal Medicine, 4th Edition, Editor-in-Chief Jay Stein, Chapters 71-72, pp. 699-715.
Dorwald F. A. Side Reactions in Organic Synthesis, 2005, Wiley: VCH, Weinheim p. IX of Preface.
http://www.fzi.uni-freiburg.de/InsectPestKey-long%20version/hemipter.htm, last accessed on Jun. 16, 2008.
David-Cordonnier, et. al., Bioorganic & Medicinal Chemistry (2004), 12(1), 23-29.
Hickman John
Koch Michel
Leonce Stephane
Michel Sylvie
Pfeiffer Bruno
Hueschen and Sage
Murray Jeffrey H
Wilson James O
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