Benzo and benzothiopyranoindazole N-oxides

Details Benzo and benzothiopyranoindazole N-oxides Benzo and benzothiopyranoindazole N-oxides

1976-03-26

1977-05-31

Todd, G. Thomas

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26029358, 260310C, 424267, 424273, C07D49506

Patent

active

040268993

ABSTRACT:
2H(1)Benzothiopyrano[4,3,2-cd]indazole N-oxides, 2H(1)benzopyrano[4,3,2-cd]indazole N-oxides and acid addition salts thereof are disclosed. These compounds can be produced by oxidation of the corresponding amines with oxidizing agents capable of forming an N-oxide derivative. The compounds are parasiticidal agents useful in the treatment of schistosome infections.

REFERENCES:
patent: 2500131 (1950-03-01), Linsker
Bickel, "The Pharmacology and Biochemistry of N--Oxides", Pharmacological Reviews, vol. 21, No. 4, pp. 325-355 (1969).
Brown, "Purine N--Oxides and Cancer," Progress in Nucleic Acid Research & Mol. Biology 8, 209-255 (1968).
Funcke et al., J. Arzneim.--Forsh. 21 (12), 2107-2109 (1971).

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