Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-08-08
2006-08-08
McKane, Joseph K. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S360000, C548S123000, C546S114000
Reexamination Certificate
active
07087621
ABSTRACT:
The present invention provides compounds of formula Ior a pharmaceutically acceptable salt, solvate, prodrug or isomer thereof and compounds of the formulaor a pharmaceutically acceptable salt, solvate, prodrug or isomer thereof.The compounds of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
REFERENCES:
Wagner et al., Ber. 1963, 96, 1177-1186 (Cas Abstract Attached).
Rabai et al. Journal of Molecular Structure 1996, 382(1), 13-21 (Cas Abstract Attached).
Du Xuhua Karen
Kadow John F.
Sang Xiaopeng
Bristol--Myers Squibb Company
Korsen Elliott
McKane Joseph K.
Nolan Jason M.
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