Benzo[.alpha.]phenazine antitumor agents

Details Benzo[.alpha.]phenazine antitumor agents Benzo[.alpha.]phenazine antitumor agents

1986-03-10

1987-08-11

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

A61K 31495, C07D24146, C07D40306, C07D40106

Patent

active

046862927

ABSTRACT:
Novel benzo[.alpha.]phenazine derivatives of the formula ##STR1## wherein R.sup.1 is hydrogen, halogen, methyl, hydroxyl or alkoxy, R.sup.2 is --COOR.sup.5 (wherein R.sup.5 is hydrogen, straight or branched chain alkyl, cycloalkyl having 3-6 carbon atoms, benzyl or phenyl) or ##STR2## wherein R.sup.6 and R.sup.7 are the same or different and are each hydrogen or lower alkyl, or R.sup.6 and R.sup.7 together with the nitrogen atom to which they are attached form pyrrolidine or piperidine), R.sup.3 and R.sup.4 are the same or different and are each hydrogen or lower alkyl, and n is an integer of 2 or 3, and the salts thereof are disclosed. These compounds have antitumor activity in mammals.

REFERENCES:
"Studies on Antitumor Activity of Phenazine Derivatives Against S 180 in Mice (VIII)," Hideo Endo, Masao Tado and Ken Katagiri, Sci. Rep. Res. Inst. Tohoku Univ.-C, vol. 16, No. 1-2, 1969, pp. 18-26.
Taisho, Chem. Abs. 101, 90980a (1984).

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