Benzo[a]pyrano[3,2-h]acridin-7-one compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Reexamination Certificate

active

10872060

ABSTRACT:
A compound selected from those of formula (I):wherein:X and Y represent a group selected from hydrogen, halogen, hydroxy, alkoxy, nitro, cyano, alkyl, trihaloalkyl and NRaRb, wherein Raand Rbare as defined in the descriptionR1represents hydrogen or alkylR2represents a group selected from hydrogen, alkyl, —OR″a, —NR′aR′b, —O-Ta-OR″a, —NR″a-Ta-NR′aR′b, —NR″a—C(O)-TaH, —O—C(O)-TaH, —O-Ta-NR′aR′b, —NR″a-Ta-OR″a, —NR″a-Ta-CO2R″aand —NR″a—C(O)-Ta-NR′aR′b, wherein R′a, R″a, R′band Taare as defined in the descriptionR3and R4represent hydrogen or alkylA represents a group of formula —CH(R5)—CH(R6)—, —CH═C(R7)—, —C(R7)═CH—, —C(O)—CH(R8) or —CH(R8)—C(O), wherein R5, R6, R7and R8are as defined in the description its isomers, N-oxides, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.

REFERENCES:
Goodman &Gilman's, The Pharmacological Basis of Therapeutics, Ninth Edition, (1996), Calabresi et al., Section X, Chemotherapy of Neoplastic Diseases, pp. 1225-1232.
Gura, T. Systems for identifying new drugs are often faulty, Science, 1997, 278:1041-1042.
Johnson et al. Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials. British J. of Cancer, 2001, 84(10):1424-1431.
Elomri et al. Synthesis and cytotoxic and antitumor activity of esters in the 1,2-dihydroxy-1,2-dihydroacronycine series. J. Med. Chem., 1996, vol. 39, pp. 4762-4766.

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