Benzo[a]phenothiazines and hydro-derivatives for inhibiting leuk

Details Benzo[a]phenothiazines and hydro-derivatives for inhibiting leuk Benzo[a]phenothiazines and hydro-derivatives for inhibiting leuk

1988-04-20

1989-10-24

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

5142245, 5142295, A61K 3154, A61K 31535, A61K 31675

Patent

active

048762466

ABSTRACT:
Pharmaceutical compositions containing a compound of Formula I: ##STR1## wherein X is O, S, SO or SO.sub.2 and R.sub.2, R.sub.3, R.sub.4 and R.sub.5 may be positioned anywhere on the structure, or a pharmaceutically-acceptable salt thereof and certain novel benzo[a]phenothiazines, which compositions and compounds are useful in treating allergic conditions, asthma, cardiovascular disorders, inflammation and pain and are useful as cytoprotective agents.

REFERENCES:
patent: 3580947 (1971-05-01), Ikeda et al.
J. Inst. Chem. (India) 49, 286-287, 1977 (Mital et al.).
J. Org. Chem. 32, 1193-1194, 1967 (Jackson et al.).
J. Org. Chem. 34, 1691-1694, 1969 (Van Allan et al.).
J. Med. Chem. 11, 622-623, 1968 (Jackson et al.).
Acta. Chim. Acad. Sci. Hung. 92, 89-97, 1977 (Agarwal et al.).
An. Org. Chem. 33B, 214-215, 1978 (Tiwari et al.).
Indian J. Chem. Sect. B, 17B, 408-409, 1979 (Tiwari et al.).
J. Het. Chem. 19, 167-169, 1982 (Ueno et al.).
Morrison et al., Org. Chem., 1966, Allyn & Bacon, Inc., Boston, pp. 96-101 & 282-290.

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