Benzo[5,6]cyclohepta[1,2-B]pyridine derivatives and antiallergic

Details Benzo[5,6]cyclohepta[1,2-B]pyridine derivatives and antiallergic Benzo[5,6]cyclohepta[1,2-B]pyridine derivatives and antiallergic

1992-01-17

1993-07-27

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 93, C07D22116

Patent

active

052311015

ABSTRACT:
Benzo[5,6]cyclohepta[1,2-b]pyridine derivatives of the following formula: ##STR1## wherein R.sup.1 represents a cyano, carbamoyl, alkylsulfoxy, alkylsulfonyl, tetrazolyl or sulfonic acid group, and R.sup.2 represents a hydrogen atom, a cyano, phenyl, aralkyl, alkoxycarbonylalkyl, aminoalkylcarbamoylalkyl or lower alkyl group, or a group ##STR2## or --X--R.sub.4, X being an oxygen or sulfur atom, R.sup.3 standing for a hydrogen atom or a substituted or unsubstituted lower alkyl, phenyl or aralkyl group, and R.sup.4 being a substituted or unsubstituted lower alkyl, phenyl or aralkyl group or an aminoalkyl group, and salts thereof. Antiallergic and antihistamic agents containing one of the above derivatives or salts as an active ingredient are also described.

REFERENCES:
patent: 4282233 (1981-08-01), Vilani
patent: 4355036 (1982-10-01), Villani
Journal of Heterocyclic Chemistry, vol. 23, No. 1, Jan.-Feb., 1986, pp. 257-263, W. Halczenko, et al., "Benzocycloheptapyridines Analogs of Azatadine", (cited Apr. 27, 1992).
Halczenko, et al. J. Heterocyclic Chemistry, 23(1), 1986, pp. 257-263.

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