Benzo[1,8]naphthyridine derivatives, their preparation and compo

Details Benzo[1,8]naphthyridine derivatives, their preparation and compo Benzo[1,8]naphthyridine derivatives, their preparation and compo

1990-10-30

1991-10-01

Shen, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

A61K 31495, C07D47106

Patent

active

050535099

ABSTRACT:
New benzo[b][1,8]naphthyridine derivatives of general formula (I), in which R.sub.1 is a hydrogen atom or a hydroxyl or alkyl radical, R.sub.2 is a hydrogen atom or an alkyl, fluoroalkyl, cycloalkyl (3 to 6 C), alkyloxy or alkylamino radical, R.sub.3 is a phenyl or phenylalkyl radical substituted with one or more halogen atoms or alkyl, cycloalkyl (3 to 6 C), alkyloxy, cyano, amino, alkylamino, dialkylamino, alkyloxyalkyl, hydroxyalkyl, hydroxyalkyloxy, methylenedioxy, aminoalkyl, alkylaminoalkyl or dialkylaminoalkyl radicals, or R.sub.3 is a heterocyclic radical, and R.sub.4 is a hydrogen atom or a fluorine atom, the alkyl radicals (1 to 4 C) being linear or branched, their salts, their preparation and compositions containing them.
These new products are useful as antimicrobials, or in the treatment of AIDS. ##STR1##

REFERENCES:
patent: 4133885 (1979-01-01), Bolhofer et al.
Schrorrenberg et al., CA 102-24611a (1985).
Antoine et al., CA 114-62083k (1991).
Antoine et al., CA 114-62082j (1991).

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