Benzisoxazole carboxylic acids

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...

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548242, 548241, 424285, C07D26120, C07D26100, A61K 3142

Patent

active

044566123

ABSTRACT:
Described are compounds of the formula ##STR1## wherein X is hydrogen, loweralkyl, halo, loweralkoxy or trifluoromethyl, and Z is hydrogen, loweralkyl, halo, hydroxy or alkoxy, or compounds of the formula ##STR2## wherein X' and Y' may be the same or different and are selected from hydrogen, loweralkyl, or halo, and Z' is hydrogen, loweralkyl, halo, hydroxy or loweralkoxy, or pharmaceutically acceptable salts thereof.
The compounds possess diuretic activity.

REFERENCES:
Limontschew, et al., "Uber Orthobenzotetraphenyldifurfuran", Monatsh 83, (1952) 137-143.
Musante, Carlo, ". . . Furochromone in Quello del Furo-benzo-isossazolo," Gazz. Chem. et al. 88, 910-929, (1958).
Bhawal, et al., "Pesticidal Activity of 1,2 Benzisoxazole . . . ", Marathwada Un. J. Sci., (1978) 17 vol. 21-2.
Hishmat, et al., "Synthesis in Furobenzoxazole . . . ", Z. Naturforsch, B. (1978) 33B(12), 1491-1495.
Limontschew, et al., ". . . Kondensation Von Benzoin und Resorcin," Monatsh 87, (1956), 399-405.

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