Benzisoxazole and benzisothizole derivatives as cholinesterase i

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

546199, 546198, 546209, 548207, 548241, 514321, C07D41312, C07D41306, A61K 31445

Patent

active

057505420

ABSTRACT:
Described herein are compounds of the formula ##STR1## wherein R.sup.1 R.sup.2, R.sup.7, R.sup.8, X, Y, M and L are defined as below. The compounds of formula I are cholinesterase inhibitors and are useful in enhancing memory in patients suffering from dementia and Alzheimer's disease.

REFERENCES:
patent: 4112105 (1978-09-01), Carlson et al.
patent: 4122176 (1978-10-01), Katsube et al.
patent: 4458075 (1984-07-01), Davis et al.
patent: 4458076 (1984-07-01), Strupczewski et al.
patent: 4461894 (1984-07-01), Omodei--Sale et al.
patent: 4528376 (1985-07-01), Strupczewski et al.
patent: 4604395 (1986-08-01), Davis et al.
patent: 4698346 (1987-10-01), Musser
patent: 4806649 (1989-02-01), Strupczewski
patent: 4963677 (1990-10-01), Sellin
patent: 5100902 (1992-03-01), Peglion et al.
patent: 5364866 (1994-11-01), Strupczewski
Adger et al., "1,2,3-Benzotriazines," J. Chem. Soc. Perkin Trans. I, pp. 31-40 (1975).
Appel, Stanley H., "Alzheimer's Disease," Neurology, 6, pp. 312-317, Month and Year Not Available.
Bartsch et al., "Phase Transfer Catalyzed Synthesis of Indazoles from o-Alkylbenzenediazonium Tetrafluoroborates," J. Heterocyclic Chem., 21, pp. 1063-1064 (1984); (Jul.-Aug.).
Becker et al., "Mechanisms of Cholinesterase Inhibition In Senile Dementia of the Alzheimer Type," Drug Development Research, 12, pp. 163-195 (1988).
Behr et al., "Pyrazoles, Pyrazolines, Pyrazolidines, Indazoles, and Condensed Rings," Heterocyclic Compounds, pp. 289-382 (1967).
Claramunt et al., "Synthesis By Phase Transfer Catalysis of N-Benzyl, N-diphenyl-Methyl and N-Triphenylmethyl Azoles and Benzazoles: Proton NMR and Chromatographic Data as a Tool for Identification," Heterocycles, 23, No. 11, pp. 2895-2906 (1985).
Crabbe et al., "Unusual Base-induced Transformations of 2',6'-Dihydroxyacetophenone Oxime," J. Chem. Soc. Perkin I, pp. 2220-2225 (1973).
Higashino, Takeo, "Takeo Higashino: On the Reaction of 4-Quinazolinecarbonitrile with Nucheophilic Reagents. II. Reaction of 4-Quinzaolinecarbonitrile with Grignard Reagents," Chem. Pharm. Bull., 10, pp. 1043-1047 (1962).
International Search Report in corresponding International Patent Application No. PCT/US 92/01605, with Notification and one-page annex; Jul. 1992.
Kalkote et al., "New Synthesis of 1,2-Benzisoxazole Derivatives," Aust. J. Chem., 30, pp. 1847-1850 (1977).
Kant et al., "Nature of Reissert Analogs Derived from N,N-Dialkyl and N,N-Diaryl Carbamoyl Chlorides," J. Heterocycl. Chem., 22, pp. 1065-1069 (1985).
McKinnon et al., "Fused Heterocycles From o-acylbenzenethiol Derivatives," Can. J. Chem., 66, pp. 1405-1409 (1988).
Oliver et al., "Alkylation and Rearrangement of Lithiated 3-Methyl-1,2-benzisoxazoles," J. Org. Chem., 54, pp. 4970-4973 (1989).
Ruchardt et al., "Aromatic Didazonium Salts. X.--A One-Pot Procecure for the Jacobson Synthesis of Indazole," Liebigs Ann. Chem., pp. 908-927 (1980).
Thakar et al., "A Modified Method for the Synthesis of 1,2-Benzisoxazoles," Indian J. Chem., 15B, pp. 1058-1059 (1977); Nov.
Uff et al., "Studies with Reissert Compounds, Part 17. Mono-Reissert Compound Formation at the 1,2-Position of the Quinazoline System," J. Chem. Soc. Perkin Trans. I, pp. 2295-2303 (1986).
Verboom et al, "`tert-Amino Effect` in Heterocyclic Synthesis. Formation of N-Heterocycles by Ring-Closure Reactions of Substituted 2-Vinyl-N,N-dialkylanilines," J. Org. Chem., 49, pp. 269-276 (1984).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Benzisoxazole and benzisothizole derivatives as cholinesterase i does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzisoxazole and benzisothizole derivatives as cholinesterase i, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzisoxazole and benzisothizole derivatives as cholinesterase i will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-979292

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.