Benzisothiazole and benzisoxazole piperazine derivatives

Details Benzisothiazole and benzisoxazole piperazine derivatives Benzisothiazole and benzisoxazole piperazine derivatives

1981-12-23

1983-10-25

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544360, 544364, 544230, 544368, 544373, C07D40100, C07D41300, A61K 3141

Patent

active

044119011

ABSTRACT:
Disubstituted N,N-piperazinyl derivatives are disclosed wherein one substituent is benzisothiazol-3-yl or benzisoxazol-3-yl and the other is alkylene attached to heterocycles such as azaspiro[4.5]decanedione, dialkylglutarimide, thiazolidinedione and spirocyclopentylthiazolidinedione or butyrophenone-like groups. The compounds have psychotropic properties and 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspior[4.5]deca ne-7,9-dione is a typical embodiment having selective antipsychotic activity.

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Jones et al., J. Chem. Soc., London, 91-92 (1946).
Benica et al., J. Am. Pharm. Assoc., 451-456 (1950).
Wu et al., J. Med. Chem. 15, 477-479, (1972).

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