Benzisothiazole and benzisoxazole piperazine derivatives

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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544360, 544364, 544230, 544368, 544373, C07D40100, C07D41300, A61K 3141

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active

044119011

ABSTRACT:
Disubstituted N,N-piperazinyl derivatives are disclosed wherein one substituent is benzisothiazol-3-yl or benzisoxazol-3-yl and the other is alkylene attached to heterocycles such as azaspiro[4.5]decanedione, dialkylglutarimide, thiazolidinedione and spirocyclopentylthiazolidinedione or butyrophenone-like groups. The compounds have psychotropic properties and 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspior[4.5]deca ne-7,9-dione is a typical embodiment having selective antipsychotic activity.

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Benica et al., J. Am. Pharm. Assoc., 451-456 (1950).
Wu et al., J. Med. Chem. 15, 477-479, (1972).

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