Benzindenolones as antiandrogenic agents

Details Benzindenolones as antiandrogenic agents Benzindenolones as antiandrogenic agents

1986-04-24

1989-07-18

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

560256, 560100, 560107, 568373, 514546, A61K 31265, C07C 6702, C07C 6976, C07C 49105

Patent

active

048494542

ABSTRACT:
Novel antiandrogenic compositions comprising an anti-androgenically effective amount of at least one compound of the formula ##STR1## wherein R is alkyl of 1 to 4 carbon atoms, R.sub.1 is alkyl of 1 to 2 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms optionally interrupted with a heteroatom, alkenyl and alkynyl of 2 to 8 carbon atoms optionally interrupted with a heteroatom, formyl and acyl of an organic carboxylic acid of 2 to 18 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.4 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, the dotted lines indicate optional presence of a double bond between the 4(5) and 5a(6) carbons and the wavy line indicates that R.sub.4 may be in the .alpha.- or .beta.-position and a non-toxic, pharmaceutical carrier or excipient and a method of treating hyperandrogenic conditions in warm-blooded animals.

REFERENCES:
patent: 4607054 (1986-08-01), Bouton et al.

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