Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-02-08
1995-02-21
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514338, 546199, 546271, C07D40112, C07D40106, A61K 31445, A61K 3144
Patent
active
053915569
ABSTRACT:
The invention relates to benzimidazolyl derivatives of general formula ##STR1## wherein R.sub.1 to R.sub.3 are defined as in claim 1, the mixtures of position isomers thereof and the salts thereof, which have valuable pharmacological properties, particularly the effect of extending the thrombin time, a thrombin inhibiting effect and an inhibiting effect on related serine proteases such as trypsin, pharmaceutical compositions containing this compound and processes for the preparation thereof.
REFERENCES:
Chemical Abstracts, vol. 113, 1990, abstract No. 6182j, Okada M. et al. "Preparation of 1,2,3,4-tetrahydroisoquinoline derivatives as antithrombotics", an abstract of JP-A-2 009 863, published on 12 Jan. 1990.
Wagner, G. et al, in Pharmazie, vol. 36, No. 9, 597-603 (Sep., 1981).
Wagner, G. et al, in Pharmazie, vol. 36, No. 9, 639-641 (Sep., 1981).
Binder Klaus
Heckel Armin
Mueller Thomas
Psiorz Manfred
Sauter Robert
Karl Thomae GmbH
Raymond Robert P.
Rotman Alan L.
Stempel Alan R.
Timbers Mary-Ellen M.
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