Benzimidazolone histamine H 3 antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C544S224000, C544S336000, C546S184000, C546S192000, C546S193000, C546S194000

Reexamination Certificate

active

10414943

ABSTRACT:
Disclosed are novel compounds of the formulawherein R1is benzimidazolone derivative, M1and M2are optionally substituted carbon or nitrogen, R2includes optionally substituted aryl or heteroaryl, and the remaining variables are as defined in the specification, and the remaining variables are as defined in the specification; also disclosed are pharmaceutical compositions comprising the compounds of formula I and methods of treating various diseases or conditions, such as allergy, allergy-induced airway responses, and congestion (e.g., nasal congestion) using the compounds of formula I, as well as methods of treating said diseases or conditions using the compounds of formula I in combination with an H1receptor antagonist.

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McLeod et al, Combined Histamine H1 and H3 . . . Am. J. Rhinology, 13, 5 (1999), p. 391-399.
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Leura et al, Therapeutic potential of histamine . . . , TiPS, 19 (1998), p. 177-183.
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Curtain et al.,Journal of Medicinal Chemistry, vol. 41 (1998) pp. 74-95.
Obase et al.,J. Heterocyclic Chemistry, vol. 20 (1983) pp. 565-573.
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