Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1979-05-16
1980-06-24
Trousof, Natalie
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
548305, C07D23526, A61K 31415
Patent
active
042095271
ABSTRACT:
A series of novel 3-(substituted methyl)-2-oxo-1-benzimidazolinalkanoic acid compounds has been prepared, including their lower alkyl esters and unsubstituted amide derivatives, as well as the base salts of said acids with pharmacologically acceptable cations. These particular compounds are useful in therapy as aldose reductase inhibitors for the control of certain chronic diabetic complications. Typical members include those compounds derived from 2-oxo-1-benzimidazoline-acetic acid wherein a benzyl moiety is substituted at the 3-position of the molecule. Methods for preparing these compounds from known starting materials are provided.
REFERENCES:
patent: 3661921 (1972-05-01), Umio
patent: 3821383 (1974-06-01), Sestanj et al.
patent: 4161603 (1979-07-01), Habermeier
Davoll et al., J. Chem. Soc. (London) C, 1960, pp. 314-318.
Pfizer Inc.
Trousof Natalie
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