Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2004-09-22
2011-11-29
O Dell, David K (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C514S322000
Reexamination Certificate
active
08067603
ABSTRACT:
The invention relates to a group of novel benzimidazolone and quinazolinone derivatives which are agonists on human ORL1 (nociceptin) receptors. The invention also relates to the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these imidazolone and quinazolinone derivatives as an active ingredient, as well as to the use of these pharmaceutical compositions for the treatment of disorders in which ORL1 receptors are involved. The invention relates to compounds of the general formula (1):wherein the symbols have the meanings as given in the description.
REFERENCES:
patent: 6262066 (2001-07-01), Tulshian et al.
patent: WO 9936421 (1999-07-01), None
patent: WO 01/39775 (2001-06-01), None
patent: WO 02/100861 (2002-12-01), None
Jenck et. al. “A synthetic agonist at the orphanin FQ
ociceptin receptor ORL1: Anxiolytic profile in the rat” Proceedings of the National Academy of Sciences 2000, 97, 4938-4943.
Wichmann et. al. “Synthesis of (1S,3aS)-8-(2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one, a potent and selective orphanin FQ (OFQ) receptor agonist with anxiolytic-like properties” European Journal of Medicinal Chemistry 2000, 35, 839-851.
Wolff, Manfred E. “Burger's Medicinal Chemistry, 5ed, Part I”, John Wiley & Sons, 1995, pp. 975-977.
Banker, G.S. et al, “Modern Pharmaceutics, 3ed.”, Marcel Dekker, New York, 1996, pp. 451 and 596.
Jones et. al. “5X-Guanidinonaltrindole, a highly selective and potent k-opioid receptor antagonist” European Journal of Pharmacology 396, 2000, 49-52.
Yoon et. al. “Roles of opioid receptor subtypes on the antinociceptive effect of intrathecal” Neuroscience Letters 441 (2008) 125-128.
Zaveri et al., “Characterization of Opiates, Neuroleptics, and Synthetic Analogs at ORL1 and Opioid Receptors”:European Journal of Pharmacology, 428:29-36 (2001).
International Search Report for PCT Application No. PCT/EP2004/052275, 2004.
Den Hartog Jacobus A. J.
Terpstra Jan-Willem
Tuinstra Tinka
Van Scharrenburg Gustaaf J. M.
Van Stuivenberg Herman H.
Dell David K O
Finnegan Henderson Farabow Garrett & Dunner L.L.P.
Solvay Pharmaceuticals B.V.
LandOfFree
Benzimidazolone and quinazolinone derivatives as agonists on... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Benzimidazolone and quinazolinone derivatives as agonists on..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzimidazolone and quinazolinone derivatives as agonists on... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4308595