Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-07-20
1995-02-21
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5483064, 5483051, A61K 31415, C07D23526
Patent
active
053915666
ABSTRACT:
Phenoxyphenylacetic acids and derivatives of the general structural formula I ##STR1## have endothelin antagonist activity and are therefore useful in treating cardiovascular disorders, such as hypertension, pulmonary hypertension, postischemic renal failure, vasospasm, cerebral and cardiac ischemia, myocardial infarction, endotoxic shock, inflammatory diseases including Raynaud's disease and asthma.
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patent: 4612323 (1986-09-01), Kisida et al.
patent: 5082838 (1992-01-01), Naka et al.
patent: 5114918 (1992-05-01), Ishikawa et al.
patent: 5187159 (1993-02-01), Greenlee et al.
patent: 5187195 (1993-02-01), Oohata et al.
Naka et al., Chemical Abstracts vol. 116 No. 13, Abstract No. 128924 (1992).
Chakravarty Prasun K.
Naylor Elizabeth M.
Tata James R.
Walsh Thomas F.
Camara Valerie J.
Daniel Mark R.
DiPrima Joseph F.
Haley Jacqueline
Lee Mary C.
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