Benzimidazolinone derivatives

Details Benzimidazolinone derivatives Benzimidazolinone derivatives

1991-04-15

1992-11-10

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514322, 514387, A61K 31535, A61K 31445, A61K 31415

Patent

active

051623188

ABSTRACT:
Benzimidazolinone derivatives of the general formula (I): ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3, which may be the same or different, each is a hydrogen or halogen atom or a lower alkyl, halo-lower alkyl, hydroxy-lower alkyl, hydroxyl, lower alkoxy, aryloxy, acyl, cyano, carboxyl, a lower alkoxycarbonyl, carbamoyl, nitro or nitrogen-containing 5- or 6-membered heterocyclic group; A is an ethylene group which may optionally have at least one branch; R.sup.4 and R.sup.5, which may be the same or different, each is a lower alkyl group or R.sup.4 and R.sup.5, together with the adjacent nitrogen atom, represent a pyrrolidinyl, piperidino or a morpholino group provided that when ##STR2## is a piperidino or diethylamino group, at least one of R.sup.1, R.sup.2 and R.sup.3 is other than a hydrogen atom, or pharmaceutically acceptable salts thereof, methods of producing the same and pharmaceutical compositions containing the same are disclosed. Pharmacologically, the above compounds (I) have pulmonary surfactant secretion promoting activity.

REFERENCES:
patent: 4154829 (1979-05-01), Mentrup et al.
patent: 4200641 (1980-04-01), Vandenberk et al.
patent: 4256756 (1981-03-01), Koppe et al.
patent: 4492708 (1985-01-01), Spitzer
Davall et al., "Some N-substituted 2-oxobenzimidazolines" J. Chem. Soc., 1960, pp. 314-318.

Affiliated with

Also associated with

Rating

Benzimidazolinone derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzimidazolinone derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzimidazolinone derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2292807