Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT

Details Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT

1992-03-04

1993-06-29

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546126, C07D45112, A61K 3146

Patent

active

052235114

ABSTRACT:
New pharmacologically active benzimidazoline-2-oxo-1-carboxylic acid derivatives which are 5-HT receptor antagonists useful as antiemetic agents and as gastric prokinetic agents of the following formula: ##STR1##
wherein R is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl or C.sub.2-6 alkynyl; R.sub.1 is hydrogen; R.sub.2 is hydrogen, halogen or C.sub.1-6 alkoxy; Y is oxygen or N--R.sub.3 in which R.sub.3 is hydrogen; A is a group selected from: ##STR2##
wherein p is 1; r is 0, 2 or 3: R.sub.4 is hydrogen; R.sub.5 is hydrogen, C.sub.1-6 alkyl, or R.sub.5 is a group of the formula --CR.sub.6 =N--R.sub.7 wherein R.sub.6 is hydrogen, C.sub.1-4 alkyl or amino and R.sub.7 is hydrogen or C.sub.1-6 alkyl; or a pharmaceutically acceptable acid addition salt thereof.
The processes for the preparation of the compounds of formula (I) as well as pharmaceutical compositions contained in them are also described.

REFERENCES:
patent: 4871744 (1989-10-01), King et al.

Affiliated with

Also associated with

Rating

Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1755668