Benzimidazole vascular damaging agents

Details Benzimidazole vascular damaging agents Benzimidazole vascular damaging agents

2011-01-25

2011-01-25

Kim, Jennifer M (Department: 1628)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S394000

Reexamination Certificate

active

07875727

ABSTRACT:
Vascular damaging agents composed of substituted 5(6)-substituted benzimidazole-2-carbamates are provided. These agents are useful in the preparation of medicaments for the treatment of diseases involving neovascularisation, particularly for the treatment of solid tumors, macular degeneration, diabetic retinopathy, rheumatoid arthritis, psoriasis, and atherosclerosis. Embodiments include a 5(6)-substituted benzimidazole-2-carbamate of formula Iwherein A represents a multi-substituted alkyl group or aromatic ring.

REFERENCES:
patent: 3694455 (1972-09-01), Dunn
patent: 3928375 (1975-12-01), Diiwel et al.
patent: 3965113 (1976-06-01), Beard et al.
patent: 3984561 (1976-10-01), Loewe et al.
patent: 5763473 (1998-06-01), Elokdah et al.
patent: 6645950 (2003-11-01), Davis
patent: 2164690 (1973-07-01), None
patent: 2332343 (1975-01-01), None
Kruse, L.I., et al., “Synthesis, Tubulin Binding, Antineoplastic evaluation, and Structure-Activity Relationship of Oncodazole Analogues,” Journal of Medicinal Chemistry, vol. 32, No. 2, Feb. 1989, pp. 409-417, XP002142971.
Lacey, E., et al., “Activity of Benzimidazole Carbamates Against L1210 mouse Leukemia cells: Correlation with in Vitro Tubulin Polymerization assay,” Biochemical Pharmacology, vol. 34, No. 19, 1985, pp. 3603-3605, XP002056333.
Chemical Abstract of de Brabander, M.J. et al., “The effects of methyl′5-(2-thienylcarbony1)-1H-benzimidazol-2-yl Carbamate, (R 17934: NSC 238159), a new synthetic antitumoral drug interfering with microtubles, on mammalian cells cultured in vitro,” p. 26, XP002143095, cited in the application abstract & Cancer Res., vol. 36, No. 3, 1976, pp. 905-916, Chemical Abstract, vol. 84, No. 21.
Khan, A.M. et al., “Studies on enteric anthelmintics: Impact of single point structural change on the activity profile, ”Zeitschrift Fur Naturfoschung, B, vol. 43, No. 2, Feb. 1988, pp. 233-237.
Raeymaekers, A.H.M., et al., “Synthesis and Anthelmintic Activity of Alkyl-(5-acyl-1H-benzimidazol-2yl) carbamates,” Arznelmittel-Forschung, vol. 28(1), No. 4, 1978, pp. 586-594, XP002142973.
Abuzar, S., et al., “Synthesis and anthelmintic activity of 2,2′-disubstitued 5,5-dibenzimidazolylsulfides and sulfones,” Arzeimittel-forschung, vol. 36(1), No. 3, Mar. 1986, pp. 416-419, XP002142974.
Database Crossfire “Online”, Beilstein Institute zur Foerderung der Chemischen Wissenschaften; XP 002142975, Beilstein Registry No. 4595458 & Indian J. Chem. Sect. B, vol. 19, No. 7, 1980, pp. 536-538.
Database Crossfire “Online”, Beilstein Institute zur Foerderung der Chemischen Wissenschaften; XP 002142976, Beilstein Registry No. 5651135 & Indian J. Chem. Sect. B, vol. 24, 1985, pp. 754-760.
Database Crossfire “Online”, Beilstein Institute zur Foerderung der Chemischen Wissenschaften; XP 002142977, Beilstein Registry No. 5622648 & Indian J. Chem. Sect. B, vol. 24, 1985, pp. 747-753.
Database Crossfire “Online”, Beilstein Institute zur Foerderung der Chemischen Wissenschaften; XP 002142978, Beilstein Registry No. 5669479, 5670801, 5667941, 5665325 & Indian J. Chem. Sect. B, vol. 24, 1985, pp. 730-732.
Database Crossfire “Online”, Beilstein Institute zur Foerderung der Chemischen Wissenschaften; XP 002142979, Beilstein Registry No. 4615289, 4609187 & Indian J. Chem. Sect. B, vol. 23, No. 12, 1984, pp. 1274-1278.
Database Crossfire “Online”, Beilstein Institute zur Foerderung der Chemischen Wissenschaften; XP 002142980, Beilstein Registry No. 6009722, 6007941, 6007769 & Indian J. Chem. Sect. B, vol. 24, 1985, pp. 178-181.
Nare et al., Biochemical Pharmacology (1994), 48(12), 2215-22.

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