Benzimidazole derivatives with antihistaminic activity

Details Benzimidazole derivatives with antihistaminic activity Benzimidazole derivatives with antihistaminic activity

1997-06-04

1999-03-02

Morris, Patricia L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546199, A61K 31445, C07D40104

Patent

active

058771875

ABSTRACT:
New benzimidazole derivatives of formula: ##STR1## in which R.sub.1 is H or a short chain hydrocarbon group such as methyl, hyl, isopropyl, cyclopropyl, vinyl, etc., and R.sub.2 is a group selected from among the following: CH.sub.2 OH, COOH, COOR.sub.3 and 4,4-dimethyl-2-oxazolinyl, R.sub.3 being a short chain alkyl group such as methyl, ethyl, etc., are described.
A description is also made of the preparation of these compounds, which have a high H.sub.1 antihistaminic and antiallergic activity and are devoid of effects on the central nervous and cardiovascular systems.

REFERENCES:
Orjales et al, "Synthesis and structure-activity, etc" CA 124:8747, 1995.

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