Benzimidazole derivatives useful as antiproliferative agents

Details Benzimidazole derivatives useful as antiproliferative agents Benzimidazole derivatives useful as antiproliferative agents

2006-03-28

2006-03-28

Raymond, Richard (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S167000, C546S170000, C514S277000, C514S311000, C514S385000, C514S396000

Reexamination Certificate

active

07019147

ABSTRACT:
The invention relates to compounds of formula (1) and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R7, R8, R9, R10, and R11are as defined herein. The invention also relates to methods of treating abnormal cell growth, such as cancer, in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula (1). The invention also relates to methods of preparing the compounds of formula (1).

REFERENCES:
patent: 5523408 (1996-06-01), Batt et al.
patent: 5578609 (1996-11-01), Batt et al.
patent: 9220642 (1992-11-01), None
patent: 9916755 (2000-04-01), None
Palmer, et al., Structure-Activity Relationships for 1-Phenylbenzimidazoles as Selective ATP Site Inhibitors of the Platelet-Derived Growth Factor Receptor; J. Med. Chem., (1998); vol. 41, pp. 5457-5465.
Palmer, et al., Structure-Activity Relationships for 5-Substituted 1-Phenylbenzimidazoles as Selective Inhibitors of the Platelet-Derived Growth Factor Receptor, J. Med. Chem., (1999); vol. 42, pp. 2373-2382.

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